Chitosan coated solid lipid nanoparticles enhance the oral absorption of insulin
Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin Article (PDF Available) in Drug Delivery and Translational Research 1(4):299-308 August 2011 with 707 ReadsThe following protocol describes the detailed steps for obtaining insulin-loaded chitosan-coated SLN. Different SLN formulations can be coated with chitosan and are presented in Table 15.1.Variations in composition and operation parameters can result in changes in the final properties of nanoparticles (e.g., size, zeta potential, polydispersity index, insulin association). Oct 24, 2015Fonte P, Nogueira T, Gehm C, Ferreira D, Sarmento B. Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Drug Deliv Transl Res. 2011; 1 (4):299–308. doi: 10.1007/s13346-011-0023-5. 123. Yang R, Gao R, Li F, He H, Tang X. The influence of lipid characteristics on the formation, in vitro release, and in vivo Oct 24, 2015Chitosan coated nanoparticles. Chitosan is a linear polysaccharide, composed of ?-(1-4)-linked d-glucosamine and N-acetyl-d-glucosamine.The hydrophilic drugs, like insulin, cannot diffuse across epithelial cells as the intestinal epithelium is a major barrier for their absorption. Mar 01, 2013Fonte P, Nogueira T, Gehm C, Ferreira D, Sarmento B. Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Drug Deliv Transl Res. 2011; 1:299–308. 88. Attivi D, Wehrle P, Ubrich N, Damge C, Hoffman M, Maincent P. Formulation of insulin-loaded polymeric nanoparticles using response surface methodology. Drug Dev Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Drug Delivery and Translational Research 2011, DOI: 10.1007/s13346-011-0023-5. Oren E Meiron, Elad Bar-David, Eliahu D Aflalo, Assaf Shechter, David Stepensky, Amir Berman, Amir Sagi. Solubility and bioavailability of stabilized amorphous calcium carbonate. Dec 08, 2006Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Drug Delivery and Translational Research 2011, DOI: 10.1007/s13346-011-0023-5. J.A. Ko, H.J. Lim, H.J. Park. Effect of microencapsulated precipitants of Lactobacillus casei ATCC 393 …Objective: In this study, Solid Lipid Nanoparticles (SLNs) were proposed to enhance the solubility and the intestinal absorption of Sb. Methods: SLNs were made of stearic acid and Brij 78 and subsequently coated with chitosan.Oral Insulin Delivery: How Far are We? Tozuka, Y, Takeuchi, H. Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin delivery. Fonte, P, Nogueira, T, Gehm, C, Ferreira, D, Sarmento, B. Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin.This Cited by count includes citations to the following articles in Scholar. Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. P Fonte, T …Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Tiago Nogueira. Download with Google Download with Facebook or download with email. Chitosan-coated cialis pills solid lipid nanoparticles enhance the oral absorption of insulin. Download. Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin.Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin. Pedro Fonte, Tiago Dias Nogueira, Christiane Gehm, Domingos Ferreira, Bruno Sarmento. Drug Delivery and Translational Research; 2011; Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin …Solid lipid nanoparticles (SLNs) have been proposed as a colloidal carrier system that could enhance the oral bioavailability of curcumin. However, a burst release of the loaded drug, which occurs in acidic environments, has been a main obstacle to the oral delivery of …Nanodelivery systems based on mucoadhesive polymer coated solid lipid nanoparticles to improve the oral intake of food curcumin Prakash Ramalingam et al 2016 Food Research International 84 113. Crossref. Synthesis of doxorubicin-PLGA loaded chitosan stabilized (Mn, Zn)Fe2O4 nanoparticles: Biological activity and pH-responsive drug releaseIn the current study, we developed resveratrol (RES)-loaded solid lipid nanoparticle (SLN-RES) in order to improve insulin resistance through the upregulation of SNARE protein complex in rats with type 2 diabetes. The SLN-RES characteristics include the following: the average size of 248 nm, the zeta potential of ? 16.5 mV, and 79.9% RES entrapment efficiency. Nov 28, 2017Oral insulin mimics the physiology of endogenous insulin secreted by pancreas. Following the intestinal absorption of oral insulin, it reaches the liver at high concentration via the portal vein. Oral insulin on the other hand has the potential to protect pancreatic ??cells from autoimmune destruction.ORIGINAL RESEARCH Oral insulin delivery by means of solid lipid nanoparticles Bruno Sarmento 1 Abstract: The aim of this work was to produce and characterize cetyl palmitate-based solid Susana Martins 1 lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal Domingos Ferreira 1 carriers for oral Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin more by Tiago Nogueira The development of alternative routes to the conventional subcutaneous administration of insulin is expected to provide an important advance in the management of diabetes.aqueous solution to form vesicular nanoparticles. The oral administration of insulin-loaded vesicles to diabetic mice resulted in the reduction of blood glucose levels - 25% of the initial glucose level - which was maintained at this level for an additional 18.5 h [21]. Solid Lipid Nanoparticles (SLN)